失眠与腺苷信号及免疫功能的研究进展
摘 要：失眠是尽管有合适睡眠环境和机会仍对睡眠时间和（或）睡眠质量不满足，并影响日间功能的一种主观体验。随着社会进步和生活节奏的加快，失眠的发病率逐渐升高并影响了人们的生活、工作。腺苷信号及免疫炎症机制参与失眠的发生，成为近年来研究的热点。本文将对失眠与腺苷信号及免疫功能的研究进展进行综述，以期探索失眠机制研究的方向和临床治疗中新的作用靶点。
关键词：失眠；睡眠障碍；腺苷；免疫稳态
中图分类号：R741 文献标识码：A DOI：10.3969/j.issn.1006-1959.2018.10.002
文章编号：1006-1959（2018）10-0004-04
Research Progress of Insomnia and Adenosine Signaling and Immune Function
REN Chong-yang1，GE Yi-jun2，ZHANG Mei3
（1.Anhui University of Science and Technology，Huainan 232000，Anhui，China；2.Chaohu Hospital of Anhui Medical University，Chaohu 238000，Anhui，China；3.The First People"s Hospital of Huainan City/The First Affiliated Hospital of Anhui University of Science and Technology，Huainan 232000，Anhui，China）
Abstract：Insomnia is a subjective experience that influences sleep time and/or sleep quality，despite having a suitable sleep environment and opportunity，and affects daytime function.With the progress of society and the acceleration of the pace of life，the incidence of insomnia is gradually increasing and affecting people"s lives and work.Adenosine signal and immune inflammation mechanism participate in the occurrence of insomnia，which has become a hot topic in recent years.This article will review the research progress of insomnia and adenosine signal and immune function，in order to explore the direction of insomnia research and new targets in clinical treatment.
Key words：Insomnia；Sleep disorders；Adenosine；Immune homeostasis
失眠（insomnia）是臨床上最常见的睡眠障碍，表现为入睡困难，夜间维持困难、早醒及无恢复感睡眠等方面，影响人的情绪状态与认知功能。其发病机制...
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