动脉粥样硬化兔不同金属基质蛋白酶动态变化的探讨
【摘 要】目的探讨不同基质金属蛋白酶在动脉硬化兔模型的动态变化。方法 高脂喂食加球囊拉伤股动脉建立动脉硬化兔模型，分别于拉伤后1、7、14、21、28 d采血，ELISA法检测MMP-1、2、8、9，TIMP-1，绘制MMPs动态变化曲线，并取血管行病理检查。结果 MMP-1、9，TIMP-1在拉伤后1 d均达到峰值，延续至拉伤后7 d；三者衍变曲线相似，且有相关性；MMP-2、8在各采血点无差异。结论 MMP-1、9，TIMP-1的动态变化规律可为研究动脉硬化不稳定斑块提供依据。
【关键词】 基质金属蛋白酶；动脉硬化；兔；动态
Dynamic changes of matrix metalloproteinses in atherosclerosis rabbit modelCHEN Jun, XU Zhao-yan. The First people′s Hospital of Feshan City, Guangdong Province, Feshan 528333, China
【Abstract】 Objective To search the dynamic changes of the matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases-1 (TIMP-1) of the atherosclerosis rabbit model．Methods Atherosclerosis models of rabbits were established through high lipid diet and injured femoral arteries by dilated balloon，and on day 1，7，14，21，28 after injured，MMP1，2，8，9 and TIMP-1 were detected with ELISA assay，then the curve reflecting the dynamic changes was draw，and the histopathology data was provided as well．Results The curve of dynamic changes MMP-1，9，and TIMP-1 were similar，the peaks were showed at 1 day after injured，and last for 7 days；there are relative among them；no obvious changes were showed in MMP-2，8．Conclusion The characteristic of dynamic changes of MMP-1,9 and TIMP-1 could provide evidence for search the vulnerable plaque．
【Key words】 Matrix metalloproteinases；Atherosclerosis；Rabbitdynamic
斑块破裂导致血小板聚集是急性冠脉综合征的病理生理学基础，较多的研究显示金属基质蛋白酶（MMPs）是斑块破裂敏感性和特异性都很高的指标[1，2]，但对不同MMPs在斑块破裂的动态变化的比较鲜有报道，本研究旨在对此进行探讨。
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