支气管肺发育不良患儿尿LTE4水平变化的临床意义
[摘要]目的 连续测定高危早产儿出生后到6个月各阶段尿中白三烯E4(LTE4)的水平,探讨其与支气管肺发育不良患儿的关系。方法 选择在本院住院的高危早产儿15例,新生儿15例。早产儿留取第2、7、14、28天的尿液,新生儿取第2、7、14、28天尿液作对照,采用酶联免疫吸附(ELISA)法检测LTE4水平。结果 正常新生儿的LTE4维持在较低的水平,早产儿一周内的LTE4水平也变化不大,14天时早产儿LTE4水平开始上升,与正常新生儿相比二者有显著性差异(P<0.01),早产儿28天后的LTE4水平维持高水平(P<0.01)。结论 LTE4是哮喘的重要炎性反应介质,与患儿吸氧、呼吸机、肺不成熟密切相关,连续监测尿液LTE4水平对早产儿支气管肺发育不良(BPD)的早期诊断、指导治疗支气管肺发育不良及改善预后具有重要作用。
[关键词] 支气管肺发育不良;新生儿;早产儿;LTE4水平
[中图分类号] R722 [文献标识码] A [文章编号] 1673-9701(2010)12-80-02
Changes of Urinary LTE4 Level in Children with Bronchopulmonary Dysplasia:Clinical Significance
HE WeihengMEI Jiaping LIANG Qiwen
Shenzhen Maternal﹠Child Healthcare Hospital,Shenzhen 518028,China
[Abstract] Objective To observe the urine leukotrienes E4 levels(LTE4) of high-risk premature babies from being born to six months and explore the relationship between bronchopulmonary dysplasia(BPD) and the urine LTE4 level. Methods According to the diagnosis criteria,the urinary LTE 4 levels of two groups(one group included 15 premature children and the other 15 full-term children) were detected on Day 2,14 and 28 respectively by enzyme-linked immunosorbent assay(ELISA) method, and the statistical analysis was made by using SPSS15.0 software. Results The urinary LTE4 of full-term children was maintained at a relatively lower level. The urinary LTE 4 level of premature children showed little change within the first 7 days,but after 14 days,the level began to rise, remarkably higher than that of the full-term babies(P<0.01), and the urinary LTE4 o...
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