地佐辛超前镇痛对腹腔镜肝切除术患者血清IL—6、IL—10及术后疼痛的影响
[摘要] 目的 评价地佐辛超前镇痛对腹腔镜肝切除患者术后疼痛及血清白介素6 （IL-6）和白介素10 （IL-10）表达的影响。方法 50例腹腔镜肝切除术患者，随机分为对照组与观察组，各25例。对照组：腹腔镜肝切除术患者未采取任何超前镇痛。观察组：腹腔镜肝切除术患者采用超前镇痛。 结果 观察组术后4、8、12、24 h的患者VAS疼痛评分均低于对照组术后4、8、12、24 h的患者VAS疼痛评分，差异有统计学意义（P<0.01）。观察组术后4、8、12、24 h的患者血清IL-6水平及血清IL-10水平均低于对照组术后4、8、12、24 h的患者血清IL-6水平及血清IL-10水平，差异有统计学意义（P<0.01～0.05）。结论 腹腔镜肝切除术后患者采用地佐辛进行超前镇痛能有效减轻伤害后疼痛，而且能有效改善患者血清IL-6、IL-10水平，保持机体内部炎性因子与抗炎性因子浓度的平衡，化解术后患者体内的代谢紊乱，降低并发症的发生率。
[关键词] 地佐辛；超前镇痛；腹腔镜肝切除术；疼痛；白介素6；白介素10
[中图分类号] R614 [文献标识码] A [文章编号] 1674-0742（2014）07（c）-0086-03
[Abstract] Objective To evaluate the effect of dezocine preemptive analgesia on the postoperative pain， serum IL-6 and IL-10 expression of patients with laparoscopic liver resection. Methods 50 patients with laparoscopic liver resection were randomly divided into control group and observation group， 25 cases in each. The control group： the patients underwent laparoscopic liver resection were not given any preemptive analgesia. The observation group： the patients underwent laparoscopic liver resection were given preemptive analgesia. Results The VAS of the observation group 4 h， 8 h， 12 h， 24 h after the operation was lower than that of the control group， respectively， the difference was statistically significant（P<0.01）. The level of serum IL-6 and IL-10 of the observation group 4 h， 8 h， 12 h， 24 h after the operation was lower than that of the control group， respectively， the difference was statisticall...
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