阿替普酶与尿激酶治疗急性肺栓塞溶栓的有效性及安全性研究
[摘要] 目的 为了提高急性肺栓塞溶栓的效果，研究采用阿替普酶与尿激酶治疗的有效性及安全性。 方法 根据患者就诊先后顺序从2016年10月”2017年10月来该院就诊的急性肺栓塞溶栓患者中方便选取60例作为研究对象，根据治疗措施的不同将其分组，其中接受阿替普酶溶栓治疗的设为观察组30例，接受尿激酶溶栓治疗的设为对照组30例，比较两组D-二聚体含量以及治疗总有效率差异。 结果 研究表明，经过2H的静脉溶栓治疗，观察组和对照组治疗的總有效率分别为28例（93.33%）和22例（73.33%），观察组总有效率更占优势，组间比较差异有统计学意义（χ2=4.32，P<0.05）；治疗前观察组和对照组患者的血浆D-二聚体含量分别为（806±59）mg/L、（799±60）mg/L，组间比较差异无统计学意义（χ2=0.578，P>0.05）；治疗后观察组和对照组患者的血浆D-二聚体含量分别为（323±82）mg/L、（272±86）mg/L，组间比较差异有统计学意义（t=2.528，P<0.05）。 结论 急性肺栓塞患者接受阿替普酶溶栓治疗，不仅能够取得较好的治疗效果，而且能够显著改善患者肺动脉收缩压水平，效果显著，值得推广和应用。
[关键词] 急性肺栓塞；阿替普酶；尿激酶；溶栓治疗；疗效
[中图分类号] R563 [文献标识码] A [文章编号] 1674-0742（2018）06（c）-0122-03
[Abstract] Objective In order to improve the efficacy of thrombolysis in acute pulmonary embolism， the efficacy and safety of alteplase and urokinase therapy were studied. Methods According to the order of patients from October 2016 to October 2017， 60 patients with acute pulmonary embolism thrombolysis who came to our hospital were convenient selected as the study objects. According to the treatment measures， they were grouped according to different treatment measures. Thirty patients in the observation group were treated with thrombolytic therapy and 30 in the control group treated with urokinase thrombolytic therapy. The D-dimer content in the two groups was compared with the total effective rate of treatment. Results Studies have shown that after 2H intravenous thrombolytic therapy，...
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