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克林霉素棕榈酸酯分散片在社区获得性呼吸道感染中的应用

材料写作网    时间: 2020-08-06 04:29:57     阅读:

摘 要 社区获得性呼吸道感染是临床常见的感染性疾病之一,具有较高的患病率,其常见的病原菌包括肺炎链球菌、流感嗜血杆菌、卡他莫拉菌、金黄色葡萄球菌及厌氧菌。本文对国内社区获得性呼吸道感染的现况进行了分析,国内几项细菌耐药性监测结果显示,青霉素、头孢菌素仍是治疗的首选,而口服克林霉素新剂型””克林霉素棕榈酸酯分散片(凯莱克林),虽然对革兰阳性菌的抗菌作用稍弱,但有毒性低,过敏反应少,口服吸收率高,胃肠道反应小,以及对厌氧菌作用好等优势,使其在社区获得性呼吸道感染的治疗中拥有一席之地,对肾功能的影响小,也使得此药在老年人中使用的安全性提高。

关键词 克林霉素棕榈酸酯分散片 社区获得性呼吸道感染 耐药性监测

中图分类号:R978.19; R563.1 文献标识码:A 文章编号:1006-1533(2015)19-0019-02

Application of clindamycin palmitate hydrochloride dispersible tablet in community-acquired respiratory tract infection

CHEN Min

(Department of Respiratory Medicine, Shanghai Tongren Hospital, Shanghai 200335, China)

ABSTRACT Community-acquired respiratory tract infection (RTI) is one of the most common clinical infectious diseases with a higher morbidity, which is generally caused by Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis, Staphylococcus aureus and anaerobes. The current situation of community-acquired RTI in China was analyze, and several nationwide surveillance of bacterial resistance indicated that penicillins and cephalosporins were still the preferred choice for the clinical treatment of community-acquired RTI. Clindamycin palmitate hydrochloride dispersible tablet (Gloria Brooklyn) is a novel oral dosage form of clindamycin. Although it is slightly less effective against gram-positive bacteria compared with the above-mentioned antibacterials, it has still captured a fair market share due to its advantages of low toxicity, less allergies, good oral absorpt...

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