肿瘤坏死因子—α抑制剂对类风湿关节炎患者血清高密度脂蛋白水平的影响
【摘 要】目的:观察肿瘤坏死因子-α(TNF-α)抑制剂对类风湿关节炎患者血清中高密度脂蛋白(HDL)水平的影响。方法:将43例类风湿关节炎患者分为治疗组23例和对照组20例。治疗组采用甲氨蝶呤联合TNF-α抑制剂治疗,对照组采用甲氨蝶呤治疗。检测2组治疗前及治疗2周、3个月后血清HDL水平。结果:治疗2周后治疗组HDL水平较治疗前升高(P < 0.01),但治疗3个月后HDL水平较治疗前无明显变化(P > 0.05)。对照组治疗2周后和3个月后HDL水平较治疗前均无明显变化(P > 0.05)。结论:TNF-α抑制剂治疗能短暂性升高类风湿关节炎患者血清HDL水平。
【关键词】 关节炎,类风湿;肿瘤坏死因子-α抑制剂;高密度脂蛋白
【ABSTRACT】Objective:To observe the effect of TNF-α inhibitor on the level of serum high density lipoprotein in patients with rheumatoid arthritis.Methods:Forty three patients with rheumatoid arthritis were divided into a treatment group(23 cases)and a control group(20 cases).The treatment group was treated with methotrexate combined with TNF-α inhibitor,and the control group was treated with methotrexate.Serum HDL levels of the two groups were measured respectively before treatment and two weeks and three months after treatment.Results:After two weeks of treatment,the level of HDL in the treatment group was higher than that before treatment(P < 0.01),but three months after treatment,the level of HDL had no significant change compared with that before treatment(P > 0.05).After two weeks and three months of treatment,the level of HDL in the control group had no significant changes compared with before treatment(P > 0.05).Conclusion:TNF-α inhibitors can transiently increase serum HDL levels in patients with rheumatoid arthritis.
【Keywords】 arthritis,rheumatoid;TNF-α inhibitors;high density lipoprotein
類风湿关节炎(rheumatoid arthritis,RA)是一种侵蚀性、对称性慢性炎性疾病,在我国发病率为0.32%~0....
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