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醛糖还原酶与炎症性疾病

材料写作网    时间: 2021-02-23 04:12:28     阅读:

[摘要] 醛糖还原酶是多元醇通路的关键限速酶,以烟酰胺腺嘌呤二核苷磷酸(NADPH)为辅酶催化醛类或酮类物质还原为相应的醇,广泛存在于肾、肾上腺、睾丸、血管、胎盘、晶状体、视网膜、神经、心脏、脑、骨骼肌、肝等组织中。醛糖还原酶是脂质过氧化过程中产生醛类谷胱甘肽-醛聚合物解毒所必须的酶。醛糖还原酶除参与继发性糖尿病并发症外,还参与心血管疾病、肿瘤、败血症、葡萄膜炎及哮喘的气道炎症过程。

[关键词] 醛糖还原酶;醛糖还原酶抑制剂;炎症;疾病

[中图分类号] R34 [文献标识码] A [文章编号] 1674-4721(2012)06(a)-0017-02

Aldose reductase and inflammatory diseases

LI Zengyu1ZHANG Huanping2▲

1.Shanxi Medical University, Taiyuan030001, China; 2.Department of Respiration, First Affiliate Hospital of Shanxi Medical University, Taiyuan030001, China

[Abstract] Aldose reductase is the key rate-limiting enzyme of the polyol pathway, and revert aldehydes or ketones to the corresponding alcohol by nicotinamide adenine dinucleotide phosphate (NADPH) as catalytic coenzyme. Aldose reductase widely present in the kidney, adrenal gland, testes, blood, placental, lens, retina, nerves, heart, brain, skeletal muscle, liver and other tissues. It""s a necessary detoxification enzyme that connected with the aldehyde-glutathione formaldehyde polymer in the process of lipid peroxidation.And that it is not only related to secondary diabetic complications, but also involved in cardiovascular diseases, cancer, sepsis, uveitis and airway inflammation in asthma.

[Key words] Aldose reductase; Aldose reductase inhibitors; Inflammation; Disease

醛糖还原酶属于醛酮还原酶超家族成员之一,是多元醇通路的关键限速酶,以烟酰胺腺嘌呤二核苷磷酸(NADPH)为辅酶催化醛类或酮类物质还原为相应的醇。于1956年Hers首次发现,精液中的果糖来源于多元醇通路,在精囊中通过醛糖还原酶催化葡萄糖产生果糖为精子提供能量[1]。醛糖还原酶广泛存在于肾、肾上腺、睾丸、血管、胎盘...

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