低分子肝素在预防结直肠癌患者术后血栓栓塞性并发症形成的临床应用
【摘要】 目的：探讨低分子肝素在预防结直肠癌患者术后血栓栓塞性并发症形成的临床应用。
方法：选取2015年6月-2017年12月在本院确诊为结直肠癌且行根治术的患者40例，按照随机数字表法将其分为试验组和对照组，各20例。对照组术后采用无抗凝药物的常规治疗方案，试验组在对照组基础上术后给予低分子肝素治疗。比较两组术后凝血酶原时间、活化部分凝血活酶时间、国际标准化比值、血栓栓塞性并发症及出血情况。结果：两组术后凝血酶原时间、活化部分凝血活酶时间、国际标准化比值比较，差异均无统计学意义（P>0.05）；试验组未出现血栓栓塞性并发症，对照组中出现4例，比较差异有统计学意义（P<0.05）；试验组1例出现瘀点、瘀斑、紫癜，对照组中未出现，比较差异无统计学意义（P>0.05）。结论：低分子肝素在预防结直肠癌患者术后血栓栓塞性并发症的形成上是有效且安全的。
【关键词】 低分子肝素； 结直肠癌； 血栓栓塞性； 预防
【Abstract】 Objective：To explore the clinical application of Low Molecular Heparin in preventing thromboembolic complications after colorectal cancer surgery.Method：A total of 40 patients were diagnosed with colorectal cancer and performed radical surgery in this hospital from June 2015 to December 2017 were selected.According to the random number table method，they were divided into experimental and control groups，20 cases in each group.The control group was treated with routine therapy without anticoagulants，and experimental group was treated with Low Molecular Heparin on the basis of control group.The postoperative thrombin time，activation of partial thrombin time，international standardized ratio，thromboembolism complications and hemorrhage between two groups were compared.Result：The postoperative thrombin time，activation of partial thrombin time，international standardized ratio in two groups were compared，the differences were not statistically significant（P>0.05）.There were no thromboembolic complications in experimental group and 4 case...
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