微量泵输注与静脉注射氯解磷定抢救急性有机磷农药中毒的疗效观察
摘要：目的 比较微量泵输注与静脉注射氯解磷定抢救有机磷农药中毒患者的临床效果。方法 回顾性分析84例急性有机磷农药中毒病例，按照随机对照原则分为A、B两组。A组患者采用常规间断静脉注射氯解磷定；B组在首次静脉注射氯解磷定后给予持续微量泵静脉维持给药。观察比较两组患者的胆碱酯酶恢复情况、住院时间、不良反应发生率、及死亡率。结果 B组患者的胆碱酯酶恢复时间（P<0.001）、住院时间（P<0.01）、不良反应发生率及死亡率（P<0.005）均低于A组。结论 微量泵输注氯解磷定抢救有机磷中毒死亡率及不良反应发生率低，并且操作简便，值得临床推广。
关键词：急性有机磷中毒；氯解磷定；微量泵
Clinical Effect Compare of Patients with Acute Organophosphate Poisoning Treated by Pralidoxime Chloride Using Intravenous Injection and Micro Pump
ZHANG Xiao-qing，LU Shao-yu
（Department of Medicine， Tianjin Fourth Hospital，Tianjin 300222，China）
Abstract：Objettive To compare The clinical effect of patients with acute Organophosphate poisoning treated by pralidoxime Chloride using intravenous injection and micro pump. Methods 84 patients with acute Organophosphate poisoning were retrospectively analyzed. The patients were divided into group A and group B. Each group has 42 cases. patients in group A were treated with intermittent intravenous injection of Pralidoxime Chloride. patients in group B were treated with continuous intravenous injection of Pralidoxime Chloride by micro pump. The recovery of cholinesterase， average length of stay in hospital ，the incidence of adverse reactions， mortality rate were compared between the two groups. Rusults The recovery time of cholinesterase（P<0.001）， average length of stay（P<0.01）， incidence of adverse reactions and mortality rate（P<0.005） .in group B were significantly less than those in group A. Conclusion Mortality rate and incidence of adverse reactions of pati...
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