基于乙肝病毒基因突变分析的乙肝个体化诊断与应用研究
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[摘要] 目的 研究乙肝病毒基因突变分析在乙肝个体化诊断方面的临床应用。 方法 选取本院自2011年8月～2014年8月间收集的乙型肝炎病毒感染未使用药物者的外周血标本和肝癌患者术后病理标本工共120例，前者为甲组，后者为乙组，对标本进行已感染HBV BCP-PreC/C区基因突变与临床诊断的相关性研究，对测得的DNA基因序列通过HBV drug guide软件进行对比分析。 结果 研究结果现实，1762/1764位的基因突变与肝脏损伤呈正向相关；1896/1899位的基因突变与HBeAg呈负向相关。 结论 本次研究为乙肝病毒基因突变分析对于乙肝个体化诊断提供一定的临床依据。
[关键词] 乙肝病毒；基因突变；分析；乙肝个体化诊断；应用
[中图分类号] R512.62 [文献标识码] B [文章编号] 2095-0616（2016）09-124-04
[Abstract] Objective To explore the clinical application of hepatitis B virus （HBV） gene mutation analysis in the individualized diagnosis of patients with hepatitis B. Methods A total 120 cases of peripheral blood samples from hepatitis B patients without any drugs and pathologic specimens from liver cancer patients after operations which were collected in our hospital form August 2011 to August 2014 were divided into group A and group B respectively.The relationship between HBV gene mutation in the BCP-PreC/C segment and clinical diagnosis was studied， and the DNA gene sequences were compared and analyzed by the HBV drug guide software. Results Results indicated that， there was a positive correlation between liver injury and gene mutation in the 1762/1764 segment，and there was a negative correlation between HBeAg and gene mutation in the 1896/1899 segment. Conclusion This paper provides a clinical reference for the individualized diagnosis of hepatitis B patients based...
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