可变剪接的理论工作研究进展
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摘要:pre-mRNA的可变剪接是调控真核生物基因表达以及蛋白质多样性的重要机制,使得可变剪接与组织分化或疾病发生有密切联系。从序列水平和表达水平对可变剪接的理论工作研究进展做了介绍,主要由相关数据库和常见的生物信息学方法两部分组成。
关键词:可变剪接;理论预测;研究进展;数据库;生物信息学方法
中图分类号:Q343.1 文献标识码:A 文章编号:0439-8114(2016)04-0820-05
DOI:10.14088/j.cnki.issn0439-8114.2016.04.002
Research Progress of Theoretical Work about Alternative Splicing
LIANG Donga,b
(a.Institute of Bioengineering and Technology,b.School of Mathematics Physics and Biological Engineering/Inner Mongolia Key Laboratory of Biomass-Energy Conversion,The Institute of Bioengineering and Technology, Baotou 014010, Inner Mongolia, China)
Abstract: The alternative splicing of pre-mRNA plays an important role in regulation of eukaryotic gene expression and diversity of protein, which made a close relation between alternative splicing and tissue differentiation or occurrence of disease. Then, this paper gives the introduction about research progress of theoretical work of alternative splicing from sequence level and expression level, which mainly is divided into relative database and common Bioinformatics Method.
Key words: alternative splicing; theoretical prediction; research progress; database; bioinformatics method
可变剪接是mRNA前体经过不同的剪接方式,形成不同的剪接异构体,最终产生不同成熟mRNA的过程。在基因可变剪接中,经过调控元件和剪接因子的相互作用,相关外显子跳跃或者保留,形成不同的组合,进而产生不同的成熟mRNA和蛋白产物[1]。所以,可变剪接可以调控基因功能,影响组织表型而产生疾病[2],例如神经系统的发育和程序...
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