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替吉奥单药与替吉奥联合多西他赛治疗老年晚期胃癌的比较

材料写作网    时间: 2021-04-02 04:06:43     阅读:次     手机站

[摘要] 目的 比较替吉奥单药与替吉奥联合多西他赛治疗老年晚期胃癌的疗效及安全性。 方法 整群选取2013年1月”2014年12月间该院肿瘤科收治的83例老年晚期胃癌患者随机分为单药组和联合组。单药组予替吉奥化疗,联合组予替吉奥联合多西他赛化疗,一周期均为21 d。化疗4周期后评价疗效及不良反应。 结果 单药组及联合组的近期疗效比较差异无统计学意义(P>0.05);单药组不良反应总体上比联合组低,其中恶性呕吐、肝功能异常发生率差异有统计学意义(P<0.05);临床获益率单药组高,两组差异有统计学意义(P<0.05)。 结论 替吉奥单药与替吉奥联合多西他赛治疗老年晚期胃癌对比,疗效相当,患者耐受性较好,不良反应减轻减少,生存质量提高。

[关键词] 替吉奥;多西他赛;老年;胃癌

[中图分类号] R4 [文献标识码] A [文章编号] 1674-0742(2015)09(a)-0151-02

Effects Comparison on the Treatment to Elderly Patients with Advanced Gastric Cancer by S-1 and S-1 Combined with Docetaxel

BI Lan-qing,ZHU Fan,ZHANG Qin-ying

Department of Oncology, North District of Suzhou Municipal Hospital, Suzhou, Jiangsu Province, 215008 China

[Abstract] Objective To evaluate the clinical efficacy and adverse reaction of the S-1 and S-1 combined with docetaxel in the treatment of elderly patients with advanced gastric cancer. Methods Eighty-three elderly patients with advanced gastric cancer were divided into trial group and control group. In the trial group, S-1 was administered orally twice daily from d1 to d14. In the control group, S-1 was administered in the same way, and intravenous of docetaxel was administered in the first day. 21 days for a cycle and continue for 4 cycles. Results For the two groups, there were no significant differences in RR and DCR(P>0.05). But there were significant differences in clinical benefit rate and partial adverse reactions as vomiting and liver function damage(P<0.05). Conclusions The...



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