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ESKAPE病原菌感染引起脓毒症的研究

材料写作网    时间: 2020-08-12 05:01:52     阅读:

摘要:感染一直是全球范围内重要的卫生问题,其中感染所导致的脓毒症发病率及死亡率极高,随着研究的深入,人们对脓毒症的认识也不断加深,2016年欧美危重病医学会制定了《脓毒症和感染性休克第三版国际共识定义》,重新定义了脓毒症。在脓毒症的众多病因中,具有突出的耐药性的ESKAPE(屎肠球菌、金黄色葡萄球菌、肺炎克雷伯杆菌、鲍曼不动杆菌、铜绿假单胞菌、肠道杆菌属)病原菌感染是其主要病因之一。ESKAPE感染的患者一般预后均较差,为了解ESKAPE所导致的脓毒症,降低其发病率和死亡率,本文主要从脓毒症、ESKAPE病原菌耐药机制,以及两者关系现状三个方面将国内外的研究进行综述。

关键词:ESKAPE病原菌;感染;脓毒症

中图分类号:R631+.2 文獻标识码:A DOI:10.3969/j.issn.1006-1959.2019.21.012

文章编号:1006-1959(2019)21-0033-04

Abstract:Infection has always been an important health problem worldwide. The incidence and mortality of sepsis caused by infection is extremely high. With the deepening of research, people"s understanding of sepsis has also deepened. 2016 Europe and the United States Critical Care Medicine The definition of "International Consensus for the Third Edition of Sepsis and Septic Shock" will be formulated to redefine sepsis. Among the many causes of sepsis, ESKAPE (E. coli, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, Enterobacter) with outstanding drug resistance Pathogen infection is one of the main causes. Patients with ESKAPE infection generally have poor prognosis. To understand the sepsis caused by ESKAPE and reduce its morbidity and mortality, this paper mainly focuses on three aspects: sepsis, ESKAPE pathogen resistance mechanism and the relationship between the two. A review of research at home and abroad.

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