生长分化因子—15水平与急性冠脉综合征患者心功能分级的相关性
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【摘要】 目的:对生长分化因子-15水平(growth differentiation factor-15,GDF-15)與急性冠脉综合征(acute coronary syndrome,ACS)患者心功能分级的临床意义进行研究。方法:58例ACS患者按纽约心脏病协会(NYHA)的心功能分级方法分为NYHA Ⅰ级组(21例)、NYHA Ⅱ级组(22例)、NYHA Ⅲ级组(10例)、NYHA Ⅳ级组(5例)四个亚组。25例行冠脉造影排除冠心病的NYHA Ⅰ级患者为对照组。检测各组B型利钠肽(B-type natnuretic peptide,BNP)等生化指标,运用ELISA法测定GDF-15水平。结果:与对照组相比,ACS患者各亚组的GDF-15、BNP水平显著高(P<0.01),且各组GDF-15、BNP水平随着心力衰竭严重程度的升高而上升(P<0.05),GDF-15、BNP水平均与心衰程度呈正相关(r=0.681、0.653,P<0.001)。且GDF-15、BNP两者间亦呈现正相关性(r=0.726,P<0.001)。结论:ACS患者的GDF-15水平升高显著,与BNP呈正相关,可对ACS患者的心功能进行较有价值的危险分层,利于判定ACS患者心力衰竭程度。
【关键词】 生长分化因子-15; 急性冠脉综合征; B型利钠肽
doi:10.14033/j.cnki.cfmr.2017.23.012 文献标识码 B 文章编号 1674-6805(2017)23-0025-03
Correlation between the Levels of GDF-15 and Heart Function Classification in Acute Coronary Syndrom/JIN Ming-feng,ZHOU Ye,CHEN Guang-hua,et al.//Chinese and Foreign Medical Research,2017,15(23):25-27
【Abstract】 Objective:To approach the clinical significance between the levels of growth differentiation factor-15(GDF-15) and the heart function classification in acute coronary syndrome(ACS).Method:58 ACS patients were divided into four sub-groups such as Ⅰ degree(21 cases),Ⅱ degree(22 cases),Ⅲ degree(10 cases),Ⅳ degree(5 cases) according to the New York heart association(NYHA).25 cases with Ⅰ degree of NYHA excluded coronary artery disease by coronary arteriography were...
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