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活性维生素D3对维持性血透患者微炎症状态的影响

材料写作网    时间: 2021-02-27 04:08:27     阅读:

【摘要】 目的:探讨活性维生素D3对维持性血液透析患者微炎症状态的影响。方法:收集60例符合慢性肾衰维持性血液透析诊断标准的患者,分为治疗组和对照组。两组均给予常规治疗,治疗组加用活性维生素D3(罗盖全),2 μg/次,2次/周,连续观察治疗12周,比较两组治疗前后超敏C反应蛋白(hs-CRP)、白介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)的变化。结果:治疗后两组hs-CRP、IL-6、TNF-α均明显降低,差异有统计学意义(P<0.05);同时,治疗组降低幅度显著高于对照组,差异有统计学意义(P<0.05)。结论:活性维生素D3通过下调维持性血液透析患者hs-CRP、IL-6、TNF-α的表达,改善微炎症反应状态。

【关键词】 维持性血液透析; 微炎症; 活性维生素D3

中图分类号 R69 文献标识码 A 文章编号 1674-6805(2013)22-0004-03

Effect of Active Vitamin D3 on the Levels of Micro-inflammation in Patients with Maintained Hemodialysis/LUO Yuan-biao,ZENG Lei,HUANG Shao-zhen.//Chinese and Foreign Medical Research,2013,11(22):4-6

【Abstract】 Objective:To investigate the effect of active vitamin D3 on the levels of micro-inflammation in patients with maintained hemodialysis.Methods: Sixty patients with maintained hemodialysis were assigned to history control group(n=30) and treatment group(n=30).Both of them treated with routine medicine treatment,while the treatment group added active vitamin D3,2μg per time,2 times per week.The treatment lasted for 12 weeks.The levels of high-sensitivity C-reactive protein,interleukin-6,tumor necrosis factor-α were measured before and after treatment.Results:The levels of hs-CRP,IL-6 and TNF-α were decrease in both groups after treatment(P<0.05).Compared with the control group,the treatment group had better therapy outcomes(P<0.05). Conclusion:Active vitamin D3 can reduce the level of hs-CRP,IL-6 and TNF-α,therefore down-regulate the micro-inflammation in patients with maintained hemodialysis.

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