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基于DKI序列的类PET成像在多发性骨髓瘤诊断中的ROC分析

材料写作网    时间: 2020-10-26 04:06:18     阅读:

[摘要] 目的 使用弥散峰度成像(DKI,diffusion kurtosis imaging)序列做全身类PET(positron emission computed tomography)扫描,将其应用于多发性骨髓瘤(MM,multiple myeloma)的诊断,分析基于DKI序列的类PET技术在多发性骨髓瘤诊断中的的可行性。 方法 方便收集南京医科大学第一附属医院在2015年11月”2017年12月发现的疑似多发性骨髓瘤患者56例,后经病理资料证实为44例为MM阳性,12例为MM阴性。将44例阳性患者作为实验组,12例阴性患者为对照组,对其做磁共振全身DKI扫描并基于DKI序列生成类PET图,对56例样本使用盲法诊断,病理结果为金标准做ROC曲线分析。 结果 对DKI诊断结果做ROC曲线分析表明,DKI对骨髓瘤检出的敏感性为90.9%,特异性为30%,ROC曲线线面积为85.3。 结论 基于DKI序列的类PET技术敏感性好,特异性稍差,可应用在多发性骨髓瘤病灶的检出诊断中。

[关键词] 全身DKI扫描;类PET技术;多发性骨髓瘤;ROC分析

[中图分类号] R445.2;R733.3 [文献标识码] A [文章编号] 1674-0742(2019)02(a)-0178-04

[Abstract] Objective To use the diffusion kurtosis imaging (DKI) sequence for whole body PET (positron emission computed tomography) scan, which is applied to the diagnosis of multiple myeloma (MM, multiple myeloma), based on DKI sequence feasibility of PET-like techniques in the diagnosis of multiple myeloma. Methods A total of 56 patients with suspected multiple myeloma who were convenient selected in the First Affiliated Hospital of Nanjing Medical University from November 2015 to December 2017 were eolled. The pathological data confirmed that 44 were MM positive and 12 were MM negative. 44 positive patients were used as experimental group, and 12 negative patients were used as control group. Magnetic resonance whole body DKI scan was performed and PET-like images were generated based on DKI sequence. 56 samples were blindly diagnosed, and pathological results were gold standard ROC curve analysis. Res...

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