D-二聚体检测判断慢性阻塞性肺疾病急性加重并肺栓塞患者预后的意义
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【摘要】 目的:探讨慢性阻塞性肺疾病急性加重(AECOPD)合并肺栓塞(PE)患者的血浆D-二聚体水平与患者首次住院日、年发作次数和生存时间的关系。方法:收集AECOPD合并PE患者136例作为观察组,检测患者血浆D-二聚体水平,记录患者的首次住院日并随访3年,记录年发作次数和生存时间,分析血浆D-二聚体水平与首次住院日、年发作次数和生存时间的相关性,同时收集无合并PE的AECOPD患者265例作为对照组。结果:AECOPD合并PE组血浆D-二聚体水平、首次住院日和年发作次数明显高于对照组(P<0.01),3年生存率则明显降低(P<0.01)。AECOPD合并PE组血浆D-二聚体水平与首次住院日和年发作次数呈正相关(r=0.623、0.784,P<0.01),与生存时间呈负相关(r=-0.677,P<0.01)。结论:AECOPD合并PE患者血浆D-二聚体水平明显升高并与患者的首次住院日、年发作次数和生存时间密切相关,可以作为患者的短期和长期预后指标。
【关键词】 D-二聚体; 慢性阻塞性肺疾病; 肺栓塞; 住院日; 年发作次数; 生存时间
doi:10.14033/j.cnki.cfmr.2019.18.027 文献标识码 B 文章编号 1674-6805(2019)18-00-03
【Abstract】 Objective:To investigate the relationship between plasma D-dimer levels and the first hospitalization days,annual attack times and survival time in patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD) complicated with pulmonary embolism(PE).Method:A total of 136 patients with AECOPD complicated with PE were collected as observation group and followed up 3 years.Plasma D-dimer levels were measured.The first hospitalization days and annual attack times and survival time were recorded.The correlation between the plasma D-dimer levels and hospitalization days,annual attack time and survival were analyzed.At the same time,265 AECOPD patients without PE were collected as control group.Result:The levels of pla...
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