老年人尿路感染常见病原菌耐药性分析
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摘要: [目的] 探讨老年尿路感染患者的常见病原菌的耐药性。[方法] 回顾性分析440例住院尿路感染患者的中段尿标本实验室检验结果。[结果] ① 住院老年患者清洁中段尿的病原菌检出率为82.9%。② 检出的365株菌株中,大肠埃希菌占40.5%,奇异变形杆菌占17.8%,肺炎克雷伯菌占12.3%,铜绿假单胞菌占8.5%,肠球菌属占6.0%。产超广谱β-内酰胺酶(ESBLs)大肠埃希菌和肺炎克雷伯菌的检出率为51.4%和42.2%。③ G-杆菌对氨苄西林、哌拉西林、环丙沙星耐药率高,对头孢哌酮舒巴坦耐药率低,对碳青酶类无耐药;G+球菌对克林霉素、克拉霉素、氧氟沙星耐药率高,对万古霉素无耐药。产ESBLs大肠埃希菌、肺炎克雷伯菌对第二、三代头孢菌素、氨苄西林、环丙沙星耐药率高,对头孢哌酮舒巴坦、丁胺卡那敏感,对碳青酶类无耐药。④ 添加酶抑制剂的抗生素对大肠埃希菌、肺炎克雷伯菌的药物敏感性极显著高于未添加酶抑制剂者。[结论] 老年人尿路感染病原菌耐药性高,头孢哌酮舒巴坦是治疗老年人尿路感染较为理想的药物。
关键词: 老年人; 尿路感染; 病原菌; 耐药性; 超广谱β-内酰胺酶中图分类号:R 37, R 69 文献标志码:
AAnalysis on antibiotic resistance of commom pathogenic bacteria among aged people with urinary tract infection
XU Wei-gang, QIN Jia-rong, PU Yu-mei, SHEN Yu, MA Jun (Shanghai Skin Diseases and STD Hospital, Shanghai 200443, China)
Abstract: [Objective] To explore the antibiotic resistance of the common pathogenic bacteria among aged people with urinary tract infection(UTI).[Methods] Specimens of middle section of urine taken from 440 cases of hospitalized patients with urinary tract infection were examined retrospectively.[Results] ① The positive rate of clean catch midstream among hospitalized aged people was 82.9%. ② A total of 365 strains of bacteria were isolated and there were 40.5% E.coli, 17.8% P.mirabilis, 12.3% P.aerugino...
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