去骨瓣减压术联合神经节苷脂对中重度颅脑损伤患者临床疗效的分析观察
[摘要] 目的 觀察去骨瓣减压术联合神经节苷脂注射液对中、重度颅脑损伤患者的临床疗效。方法 方便选取2015年9月”2016年9月于厦门市第五医院神经外科住院治疗的40例中、重度颅脑损伤患者随机分为两组，对照组给予紧急对症处理并行去骨瓣减压术，观察组在对照组基础上加用神经节苷脂注射液静脉滴注，比较各组患者治疗前、治疗28 d后的临床效果、脑源性神经营养因子（BDNF）、神经功能缺损程度分型（NFD）、日常生活能力（ ADL）恢复情况。 结果 治疗28 d后，观察组与对照组相比，BDNF明显升高（3.05±0.29）ng/mL，（t=3.875，P=0.027）， NFD降低（7.88±3.35）分（t=2.473，P=0.019），改良Barthel指数明显升高（45.61±4.63）分（t=6.345，P=0.012）。根据总有效率，观察组明显高于对照组（95%）（χ2=5.813，P=0.025）。结论 去骨瓣减压术联合神经节苷脂通过提高大脑BNDF的含量，改善患者的神经功能及日常生活能力，进一步增加疗效及预后。
[关键词] 去骨瓣减压术；神经节苷脂；中重度颅脑损伤；脑源性神经营养因子
[中图分类号] R651.1 [文献标识码] A [文章编号] 1674-0742（2018）07（c）-0009-04
Analysis of Clinical Efficacy of Decompressive Craniectomy Combined with Gangliosides in Patients with Moderate to Severe Craniocerebral Injury
LIAN Jian-zhu
Department of Neurosurgery， the Fifth Hospital of Xiamen， Xiamen， Fujian Province， 361101 China
[Abstract] Objective To observe the clinical efficacy of decompressive craniectomy combined with ganglioside injection in patients with moderate or severe craniocerebral injury. Methods 40 patients with moderate or severe craniocerebral injury admitted to the Department of Neurosurgery at the Fifth Hospital of Xiamen from September 2015 to September 2016 were convenient selected and divided into two groups. The control group was given emergency symptomatic treatment and decompressive craniectomy. The observation group was treated with ganglioside injection intravenously on the basis of the control group. The clinical effects...
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