我院肠杆菌属ESBLs耐药情况及CTX-M-1、SHV型耐药基因研究
打开文本图片集
【摘 要】目的：了解2016-2018年本院肠杆菌属分布情况及部分耐药基因分型。方法：利用WHONET5.6软件分析耐药率变化。针对产ESBLs酶菌株进行CTX-M-1、SHV型耐药基因分型。结果：2016-2018年期间共得到肠杆菌属124株;大多数菌株来自神经外科（19%），标本类型主要为痰（56%）;肠杆菌属对青霉素类、头孢菌素类、单环β-内酰胺类抗菌素均存在较高耐药率（>20%），对复方新诺明的耐药率明显呈上升趋势。有46（37.1%）株对ESBLs耐药菌株，主要为CTX-M-15型（21.7%）。结论：建议通过更多的研究建立一套完整的基因耐药监测体系。
【关键词】肠杆菌属;ESBLs;耐药;CTX-M-1;SHV
Abstract：Objective To understand the distribution of Enterobacter and the types of drug resistance genes in the isolated specimens of our hospital from 2016 to 2018. Methods：The change of drug resistance rate was analyzed by WHONET5.6 software. CTX-M-1 and SHV-type genotyping were performed on strains producing ESBLs.Results： A total of 124 strains of Enterobacter were obtained during 2016-2018;Most of the strains were from neurosurgery（19%）.The type of specimen was mainly sputum （56%）; Enterobacteriaceae have high resistance rate to penicillins，cephalosporins and monocyclic β-lactam antibiotics， which is more than20%.The resistance rate of Nomin is rising clearly. There were 46（37.1%）strains resistant to ESBLs， mainly CTX-M-15（21.7%）.Conclusions：It is suggested that a complete set of genetic drug resistance monitoring procedures should be established through more research.
Key words： Enterobacter;ESBLs;Drug resistance;CTX-M-1;SHV
【中图分类号】R378.2 【文献标识码】A 【文章编号】1005-0019（2019）20-0-02
肠杆菌属隶属于肠杆菌科，广泛分布于自然环境中，目前已经发现的包括14种[1]，是重要的在院内感染...
|
== 试读已结束，如需继续阅读敬请充值会员 ==
|
|
本站文章均为原创投稿，仅供下载参考，付费用户可查看完整且有格式内容！
(费用标准：38元/2月，98元/2年，微信支付秒开通！) |
| 升级为会员即可查阅全文 。如需要查阅全文，请 免费注册 或 登录会员 |
|
