加替沙星治疗急性下呼吸道细菌感染的研究
[摘要] 目的:研究加替沙星序贯疗法治疗急性下呼吸道细菌感染的疗效和安全性。方法:对46例急性下呼吸道细菌感染患者,采用加替沙星0.2 g,bid,6~8 d静脉滴注,继之以0.4 g,qd,4~7 d,口服。结果:痊愈14例(30.43%),显效28例(60.87%),改善4例(8.70%),总有效率为91.30%,细菌消除率为95.66%,总疗程为10~15 d,平均(12.0±2.7) d,药物副作用较少,发生率为2.17%。结论:加替沙星序贯疗法治疗急性下呼吸道细菌性感染有效、安全。
[关键词] 加替沙星;细菌感染;下呼吸道感染
[中图分类号] R978.1 [文献标识码]B [文章编号]1674-4721(2010)06(c)-051-02
Treatment of acute lower respiratory tract bacterial infection by gatifloxacin
TAO Xiufang
(Gaomi Municipal Hospital, Shandong province, Gaomi 261500, China)
[Abstract] Objective: To study the efficacy and safety of gatifloxacin in the treatment of acute lower respiratory tract bacterial infection (ALRTBI)by sequential therapy. Methods: Forty six patients with ALRTBI were treated with gatifloxacin iv drip in a regimen of 0.2 g bid for 6-8 d then with oral gatifloxacin dose of 0.4 g qd for 4-7 d in sequence. Results: An effective rate was 91.30% and a bacterial eradication rate was 95.66%, the tolerable side effect was 2.17%. Conclusion: Gatifloxacin sequential therapy is an effective and safe agent for treatment of acute lower respiratory tract bacterial infection.
[Key words] Gatifloxacin; Bacterial infections; Lower respiratory tract infection
加替沙星(gatifloxacin)是近年来新研制的第四代喹诺酮类药物,其生物利用度高,组织分布广,抗菌谱比以往的氟喹诺酮类更广泛,不仅对临床常见的革兰阳性及阴性菌、厌氧菌具有良好的治疗作用,对支原体和衣原体感染亦有较强作用,能有效地用于多种感染。为观察加替沙星治疗急性细菌感染的临床疗效和安全性,笔者采用序贯用药治疗46例急性下呼吸道细菌性感染患者,现将结果报道如下:
1 资料与方法
1.1 一般资料
46例均为2009年4~10月在本科确诊为急性下呼吸道细菌性感染的患者,原发...
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