我院2007~2009年病原菌分布及其耐药性结果分析
摘 要 目的：了解病原菌的变迁和耐药性，指导抗菌药物合理使用。方法：回顾性分析2007～2009年的病原菌及其耐药性。结果：1864株病原菌中革兰阴性菌1080株（58%）、革兰阳性菌281株（15%）、真菌503株（27%）。3年来，临床分离菌G->/sup>杆菌及G+>/sup>球菌增加，真菌感染有逐年降低趋势。位于前3位的革兰阴性菌和革兰阳性菌分别是大肠埃希菌、铜绿假单胞菌、肺炎克雷伯菌和金黄色葡萄球菌、凝固酶阴性葡萄球菌、屎肠球菌。碳青酶烯类仍是对革兰阴性菌抗菌作用最强的一类抗菌药物。未发现耐万古霉素的葡萄球菌和屎肠球菌。结论：细菌耐药性仍呈增长趋势，应引起注意，加强病原菌的感染监控，为合理使用抗菌药物提供依据。
关键词 病原菌 耐药性 监测
AbstractObjective:To observe bacterial changing～pattern and drug-resistant pattern for reasonable application of antibiotics.Methods:We reviewed the data of 2007-2009 pathogens tests.Results:Of 1864 isolated pathogens ,1080（58%） were Gram-negative bacilli,281（15%） were Gram-positive cocci and 503（27%） were fungi.Over the 3 years,Gram-negative bacilliin and Gram-positive cocci strains causing hospital nosocomial infections increased,but fungous infection showed a decline tendency.The most common Gram-negative bacilli were Escherichia coli,Pseudomonas aeruginosa and Klebsiella spp While the most common Gram-positive cocci were S.aureus,methicillin-resistant coagulase-negative Staphylococcus.and Enterococcus faecium.Carbapenems were the most active antibiotics tested against Gram-negative organisms.Neither strains of Staphylococcus nor strains of Enterococcus faecium were found resistant to vancomycin.Conclusions:Intensification of monitoring pathogens causing hospital nosocomial will give information about bacterial prevalence and changing-pattern,which therefore will provide scientific basis for use of antibiotics.
Key wordsPathogens;Antibiotic;Resistance;Survey
细菌耐药性是当前感染领域中的重大课题和难点。...
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