低温时蛙皮素对IL-1β致热大鼠的降温作用及与PGE2的相关性
[摘要] 目的：探讨4℃时蛙皮素（BN）的降温作用及其机制。方法：在4℃环境下，以IL-1β致热大鼠为研究对象，采用放免法对下丘脑和血浆中前列腺素E2（PGE2）含量进行同步检测。结果：在IL-1β诱导发热大鼠中，下丘脑及血浆中PGE2含量显著升高（P<0.01、P<0.05）；BN降低大鼠正常体温，PGE2含量亦随之显著降低（P<0.01、P<0.05）；预先侧脑室注射BN能翻转大鼠IL-1β性发热，且PGE2含量亦明显下降（P<0.01、P<0.05）。结论：低温时BN能降低大鼠正常体温和抑制IL-1β性发热，其机制可能是通过抑制PGE2合成与释放实现的。
[关键词] 蛙皮素 白细胞介素-1β 前列腺素E2 发热
[中图分类号] R965 [文献标识码]A[文章编号]1673-7210（2011）02（b）-021-03
Hypothermia function of bombesin in IL-1β induced fever rats and its correlation with PGE2 at low temperature
ZHANG Liang, SUN Dayu, JIANG Min
(Department of Physiology, the Basic Medical College of Shenyang Medical College, Shenyang 110034, China)
[Abstract] Objective: To analyze the hypothermia action of bombesin and its mechanism on the rats at 4℃. Methods: The content of PGE2 had been detected by radioimmunoassay in hypothalamus and serum of IL-1β induced fever rats at 4℃. Results: The level of PGE2 increased progressively in hypothalamus and plasma of the rats (P<0.01, P<0.05); bombesin could decrease normal body temperature of rats. Simultaneously, the content of PGE2 were lower (P<0.01, P<0.05); fever induced by IL-1β could be reversed by pretreatment with injected bombesin in paracoele of rats. Compared with the control group, the content of PGE2 was lower (P<0.01, P<0.05). Conclusion: The present study demonstrates that bombesin could inhibit IL-1β induced fever at low temperature, and the mechanism might be achieved by inhibition of PGE2 synthesis.
[Key words] Bombesin (BN); Interlukin-1β (IL-1β); Prostaglandin E2 (PGE2); Fever
蛙皮素...
|
== 试读已结束，如需继续阅读敬请充值会员 ==
|
|
本站文章均为原创投稿，仅供下载参考，付费用户可查看完整且有格式内容！
(费用标准：38元/2月，98元/2年，微信支付秒开通！) |
| 升级为会员即可查阅全文 。如需要查阅全文，请 免费注册 或 登录会员 |
|
