补充维生素D在慢性丙型肝炎患者聚乙二醇干扰素联合利巴韦林抗病毒治疗中的作用
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[摘要] 目的 研究维生素D在慢性丙型肝炎(CHC)患者接受聚乙二醇干扰素α-2b(Peg-IFNα-2b)联合利巴韦林(RBV)抗病毒治疗中的作用。 方法 本研究为前瞻性随机对照试验,共纳入52例CHC初治患者,随机分为维生素D补充治疗组(A组)、对照组(B组),A组26例患者口服补充维生素D 800 IU/d至Peg-IFNα-2b/RBV抗病毒治疗结束,B组26例患者仅接受Peg-IFNα-2b/RBV抗病毒治疗。检测患者治疗前、治疗4周、12周、24周、48周时HCV RNA水平等指标。 结果 治疗24周、48周时维生素D补充治疗组病毒学应答率均显著高于对照组(95.8% vs 69.6%,95.8% vs 73.9%,P均<0.05),但两组早期病毒学应答(EVR)无统计学差异(91.7% vs 69.6%,P>0.05)。两组不良事件发生率并无差异(73.1% vs 80.8%,P>0.05)。 结论 补充维生素D能提高CHC患者Peg-IFNα-2b/RBV抗病毒疗效。
[关键词] 慢性丙型肝炎;维生素D;干扰素;利巴韦林
[中图分类号] R512.63;R575.2 [文献标识码] A [文章编号] 1673-9701(2017)04-0023-05
Effect of vitamin D supplementation on the antiviral therapy of pegylated interferons combined with ribavirin in the patients with chronic hepatitis C
LIU Minhui1 CHEN Haijun1 ZHANG Dehe1 TANG Hui2
1.Department of Infection, Jinhua Central Hospital in Zhejiang Province, Jinhua 321000, China; 2.Institute of Viral Hepatitis, Chongqing Medical University, Chongqing 400016, China
[Abstract] Objective To study the effect of vitamin D on the antiviral therapy of pegylated interferon α-2b(Peg-IFNα-2b) combined with ribavirin(RBV) in the patients with chronic hepatitis C(CHC). Methods The study was a prospective, randomized and controlled trial. A total of 52 patients with CHC were eolled in this study. They were randomly divided into vitamin D supplementation group (group A), contro...
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