髓样分化蛋白-2研究进展
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摘要 髓样分化蛋白-2(Myeloid differentiation protein-2,MD-2)是一种分子量为20~30 kD的分泌蛋白,它结合在Toll样受体4(Toll-like receptor 4,TLR4)胞外区,能与TLR4组成复合体(MD-2/TLR4),在细菌脂多糖(lipopolysaccharide,LPS)的识别及其信号转导中发挥重要作用,MD-2也是目前炎症、感染、免疫等病理过程研究的热点之一。本文对MD-2基因结构、基因表达及MD-2与机体天然免疫等方面研究结果进行综述,以期阐释MD-2的基因与天然免疫的关系,为揭示MD-2基因的功能提供技术参考。
关键词 MD-2;TLR4;信号转导;天然免疫
中图分类号 Q71 文献标识码 A
文章编号 1007-5739(2019)19-0210-03 开放科学(资源服务)标识码(OSID)
Research Progress on Myeloid Differentiation Protein-2
WANG Zhi-han LUO Yi-chen SHUAI Xue-hong GU Guo-jing LI Bo-wen LI Wen-jie ZHOU Zhi-xiong ZHAO Yu WU Li CHEN Ji-xuan HUANG Qing-zhou JIAO Han-wei *
(College of Animal Sciences,Veterinary Scientific Engineering Research Center,Southwestern University,Chongqing 402460)
Abstract Myeloid differentiation protein-2 is a kind of molecular weight of 20-30 kd secreted protein,it combines the toll-like receptor 4(TLR4)extracellular area,and forms a complex with TLR4(MD-2/TLR4).In the recognition and signal transduction of LPS,it plays an important role,too.Futhermore,MD-2 is one of the hottest spot of research such as the inflammation,infection,and immune pathological process.This paper summarized the structure,gene expression of MD-2 and innate immune reaction to MD-2,in orde...
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