蛋白质芯片技术的临床应用新进展
【摘要】 近年来,生物芯片技术日趋成熟,这其中,蛋白质芯片技术以其自动化、微型化、高灵敏度、高通量、高特异性等优点,被广泛地应用于蛋白质组学的研究中,并发挥着越来越大的作用。同时,由于此技术能快速、准确地找到细胞与组织在不同环境与状态下蛋白质表达的差异,因此在肿瘤、传染性疾病以及自身免疫性疾病的早期诊断中具有巨大的应用潜能。本文对蛋白质芯片技术的原理、分类与其在临床中的最新应用进展作一总结。
【关键词】 蛋白质芯片; 肿瘤; 传染性疾病; 自身免疫性疾病; 早期诊断
The Latest Advances of Clinical Application on Protein Chip Technology/XIE Lin-feng,XIANG Jun-bei,SUN Ya-nan,et al.//Medical Innovation of China,2015,12(23):154-156
【Abstract】 In recent years,biochip technology becomes more mature.Among these,the protein chip technology is playing an increasingly important role in proteomics research for its advantages of automation,miniaturization,high sensitivity,high-throughput and high specificity.Meanwhile,because this technology can quickly and accurately find the difference of protein expression of cells and tissues in different environments and state,it has enormous application potentiality in the early diagnosis of cancer,infectious diseases and autoimmune diseases.This paper makes a summary on the principle and classification of protein chip technology and the progress in its latest clinical application.
【Key words】 Protein chip; Tumor; Infectious diseases; Autoimmune diseases; Early diagnosis
First-author’s address:Sichuan Nursing Vocational College,Chengdu 610100,China
doi:10.3969/j.issn.1674-4985.2015.23.054
近年来,随着基因组技术的不断完善以及基因组计划的发展,人类已经获得了包括人类自身在内的3173个物种的全部基因序列(Genome Online Database,http://www.genomesonline.org),这为学者提供了巨量的遗传信息资源,推动着生命科学向着更加个性化、精确化以及规模化的方向发展,...
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