2010至2017年间4760株常见革兰阴性非发酵菌及其耐药性动态变迁分析
【摘要】目的了解亞胺培南对革兰阴性非发酵菌的耐药性及其变化趋势，为临床合理用药提供依据。方法收集2010～2017年间从右江民族医学院附属医院就诊患者标本分离的革兰阴性非发酵菌，进行鉴定及药敏试验，并对结果进行统计分析。结果4760株革兰阴性非发酵菌分离自痰液、脓液、尿液及血液等标本，主要包括铜绿假单胞菌（4403%）、鲍曼不动杆菌（31.62%）、嗜麦芽窄食单胞菌（9.64%）和洋葱伯克霍尔德菌（2.63%）等菌株。铜绿假单胞菌和嗜麦芽窄食单胞菌对大部分常见抗菌药物耐药率低于10%，鲍曼不动杆菌对大部分常见抗菌药物耐药率高于30%，洋葱伯克霍尔德菌对部分常见抗菌药物耐药率高于70%。铜绿假单胞菌对亚胺培南的耐药率较低且逐年下降，鲍曼不动杆菌对亚胺培南的耐药率较高且波动较大，洋葱伯克霍尔德菌对亚胺培南耐药率较高且波动不大。结论亚胺培南对铜绿假单胞菌抗菌活性较强，但对鲍曼不动杆菌和洋葱伯克霍尔德菌抗菌活性较差，应引起关注。
【关键词】革兰氏阴性非发酵菌；亚胺培南；耐药性分析；多重耐药菌
中图分类号：R915 文献标识码：ADOI：10.3969/j.issn.10031383.2018.02.006
Analysis of 4760 Gramnegative nonfermentative bacteria and
their dynamic changes of drug resistance from 2010 to 2017
YI Xueli，LUO Bin，TENG Yuanji，DENG Ying，WEI Ying
（Department of Laboratory，Affiliated Hospital of Youjiang Medical University for Nationalities，Baise 533000，China）
【Abstract】ObjectiveTo understand the resistance of imipenem to Gramnegative nonfermentative bacteria and its changing trend，so as to provide evidence for rational clinical use of antimicrobial drugs.MethodsGramnegative nonfermentative bacteria isolated from the specimens of patients from the Affiliated Hospital of Youjiang Medical University for Nationalities from 2010 to 2017 were collected for identification and drug sensitivity test，and the results were statistically analyzed.Results4760 Gramnegative nonfermentative bacteria were isolated from the samples of sputum，pus，urine and blood，including Pseudomonas aerugi...
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