结肠癌组织MTSS1与SOX2在结肠癌组织中的表达及其与临床病理的关系
[摘要] 目的 分析转移抑制因子1（MTSS-1）及胚胎干细胞关键蛋白（SOX2）在结肠癌组中表达及与临床病理关系。 方法 选取2016年1月～2017年6月秦皇岛市第一医院收治的80例结肠癌患者作为研究对象，采用二步法免疫组织化学方法检测患者的结肠癌组织中MTSS1及SOX2表达水平，并分析临床病理特征与MTSS1及SOX2表达的相关性。 结果 结肠癌组织中MTSS1及SOX2蛋白阳性表达率均显著低于癌旁毗连区，差异有统计学意义（P < 0.01）；不同分化程度、淋巴结转移、Dukes分期患者肿瘤组织中MTSS1及SOX2阳性表达率差异有统计学意义（P < 0.01）；分化程度是MTSS1阳性表达的危险性因素（P < 0.05），分化程度及淋巴结转移是SOX2阳性表达的危险性因素（P < 0.05）。 结论 结肠癌组织MTSS1与SOX2在结肠癌组织中的表达与分化程度密切相关，且淋巴结转移与SOX2表达显著相关。
[关键词] 结肠癌；MTSS1；SOX2；临床病理
[中图分类号] R574.62 [文献标识码] A [文章编号] 1673-7210（2018）05（b）-0080-03
Expression of MTSS1 and SOX2 in colon cancer tissue and its relationship with clinicopathological characteristics
LIU Qingbin1 CHEN Yanxin2 XIAO Fang2 ZHOU Ying2 ZHANG Hui2
1.Department of General Surgery， Qinhuangdao City No.1 Hospital， Hebei Province， Qinhuangdao 066000， China；2.Department of Pathology， Qinhuangdao City No.1 Hospital， Hebei Province， Qinhuangdao 066000， China
[Abstracts] Objective To analyze the relationship between the expression of MTSS-1 and SOX2 and clinicopathological in colon cancer. Methods From January 2016 to June 2017， 80 cases colon cancer patients， who were treated in Qinhuangdao City No.1 Hospital were selected as the research object， the levels of MTSS1 and SOX2 expression were tested by two step immunohistochemical method， and the clinical and pathological features of MTSS1 and SOX2 expression correlation were analyzed. Results The positive expressions of MTSS1 and SOX2 protein in colon cancer tissues were significantly l...
|
== 试读已结束，如需继续阅读敬请充值会员 ==
|
|
本站文章均为原创投稿，仅供下载参考，付费用户可查看完整且有格式内容！
(费用标准：38元/2月，98元/2年，微信支付秒开通！) |
| 升级为会员即可查阅全文 。如需要查阅全文，请 免费注册 或 登录会员 |
|
