溃疡性结肠炎与肺栓塞
【摘要】 目前肺栓塞（pulmonary embolism，PE）仍被误认为是一少见病，实际上是常见的，其发病率在心血管中居于第3位，仅次于冠心病与高血压，病死率高达20%～30%。PE虽然凶险，然而是可预防可治疗的，提高对该病的认识，采取早期预防对预后具有重要意义。众所周知，PE危险因素包括深静脉血栓形成、高龄、卧床、手术、妊娠，肿瘤等，国内外曾报道多例溃疡性结肠炎（ulcerative colitis，UC）患者发生PE病例，本文主要对两者关系及作用机制作一综述，望临床工作者提高对UC的认识。
【关键词】 溃疡性结肠炎； 高凝状态； 肺栓塞
【Abstract】 At present，pulmonary embolism（PE）is still considered as a rare disease，it is common in fact.According to statistics，the incidence of PE is third in the cardiovascular disease，behind coronary heart disease and hypertension，the mortality is as high as 20%-30%.Despite the high risk of PE，while it can be prevented and treated，improving the recognition and taking early prevention is of great significance to the prognosis.It is well known that risk factors of PE including deep venous thrombosis，elder，lying in bed，surgery，pregnancy，cancer，et al.It is reported that ulcerative colitis can lead to PE，this article mainly discusses the relationship and mechanism on the two diseases，hope to improve clinical staff awareness of UC.
【Key words】 Ulcerative colitis； Hypercoagulative state； Pulmonary embolism
First-author’s address：The Central Hospital of Jilin City，Jilin 132011，China
doi：10.3969/j.issn.1674-4985.2016.07.044
溃疡性结肠炎（ulcerative colitis，UC）是一种以大肠黏膜及黏膜下炎症为特点的炎症性肠病，多见于20～40岁，我国统计20年内患病率约为11.6/10万[1-2]。UC的病因尚不完全清楚，现学者一致认为UC是一种自身免疫性疾病。近年来的研究还表明UC患者血液呈高凝状态，发生血液系统疾病概率为1%～8%，其中以血栓栓塞最常见。早在1936年，Bargen和Barker 首次报道了活动性UC患者中存在严重的致命的血栓栓塞事件，随后Tal...
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