脑卒中并发尿路感染患者的病原学调查及临床干预
【摘要】目的:调查社区医院病房中脑卒中后遗症并发尿路感染患者的常见致病菌并筛选适合的抗菌素经验用药。方法 首先进行回顾性研究，通过细菌培养了解我院病房中脑卒中后遗症并发尿路感染的常见病原菌，并通过药敏实验筛选出敏感抗菌素；然后通过前瞻性随机对照研究，将患者随机分为以往经验用药（左氧氟沙星针）和筛选用药（阿米卡星针）两组进行治疗，观察比较两组的治疗效果和不良反应以筛出今后经验敏感药物。结果 以往经验用药组有效率为21.6%，而筛选组有效率为76.6%，两者比较有统计学显著差异；而两者均无严重不良反应。结论 社区医院病房中脑卒中后遗症并发尿路感染的主要致病菌是大肠埃希菌，治疗社区医院病房中脑卒中后遗症并发尿路感染，筛选用药（阿米卡星针）的疗效优于以往经验用药（左氧氟沙星针）。
【关键词】脑卒中；尿路感染；阿米卡星；左氧氟沙星
【中国分类号】R743.3【文献标识码】A【文章编号】1044-5511（2011）11-0476-02
【Abstract】Objective: This study was undertaken to find the most common pathogen of urinary infection after stoke patients in inpatient ward of community hospital and screen the ideal antibiotic. Methods: Firstly, a retrospective research was performed to find the most common pathogen of urinary infection after stoke patients of our hospital by pathogen culture and select the sensitive antibiotics by drug sensitive test. Then we designed a prospective randomized controlled test to compare the therapeutic effects and adverse events of levofloxacin and amikacin for treating urinary infection to further decide which one can be the ideal antibiotic for such kind of patients. Results: The effective rate of Amikacin (76.6%), which was selected from the former retrospective research, was significantly higher than that of levofloxacin (21.6%)。 No severe adverse event was observed. Conclusions: The most common pathogen of urinary infection after stoke patients in inpatient ward of our hospital was Eschericha Coli....
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