鲍曼不动杆菌耐药性监测与外排泵adeB基因存在状况分析
摘要：目的 探讨我院临床分离鲍曼不动杆菌的耐药性及外排泵adeB基因存在状况。方法 WHONET5.6回顾性分析鲍曼不动杆菌耐药性，聚合酶链反应(PCR)扩增检测adeB基因。 结果 2011年，鲍曼不动杆菌对头孢菌素类、碳青霉烯类、β-内酰胺酶抑制剂、氟喹诺酮类和氨基糖苷类抗菌药物均较敏感，耐药率几乎均在40%以下，2012年出现较大幅度上升，对5大类抗菌药物的耐药率几乎均在50%以上，2013年变化不明显；鲍曼不动杆菌外排泵adeB基因阳性率高(80.9%)，多重耐药菌adeB基因阳性率(89.7%)明显高于相对敏感菌adeB基因阳性率(37.5%)(P<0.05)。结论 鲍曼不动杆菌耐药情况严重，adeB基因阳性率高；主动外排在鲍曼不动杆菌多重耐药中可能发挥重要作用。
关键词：鲍曼不动杆菌；外排泵；adeB基因
Investigation of Acinetobacter Baumannii Drug Resistance and Analysis of Existence of Efflux Pump AdeB Gene
WU Ze-cai1,DENG Zheng-hua1,LUO Qian2
(1.Department of Laboratory Medicine,The Affiliated Hospital of Luzhou Medical College,Luzhou 646000,Sichuan,China; 2. Department of Laboratory Medicine, The First People"s Hospital of Neijiang City, Luzhou 646000,Sichuan,China)
Abstract：Objective To investigate the drug resistance of Acinetobacter baumannii clinical isolates in our hospital and the existence of efflux pump adeB gene. MethodsAnalysis retrospectively of drug resistance of Acinetobacter baumannii based on WHONET5.6. And the polymerase chain reaction(PCR)was used to amplify the adeB gene. ResultsIn 2011, acinetobacter baumannii were sensitive to the cephalosporin class, carbon penicillium alkene, β- lactamase inhibitor, fluoroquinolone and aminoglycoside antibiotic drugs, The resistant rates to almost were all below 40%.But it appeared a relatively substantially rise in 2012, the resistance rates to five categories of antibacterial drug were all above 80%.there were no change obviously in 2013.The rate of efflux pump adeB gene in acinetobacter baumann...
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