高危型HPV检测对意义不明确的宫颈不典型鳞状细胞的分流价值
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摘要：目的 探讨不典型鳞状细胞（ASCUS）的临床意义、进一步处理措施以及高危型人乳头病毒（HR-HPV）检测的分流作用。方法 对宫颈薄层液基细胞学诊断为ASCUS的160例患者分别进行HR-HPV检测、阴道镜下活组织检查。结果 在HR-HPV阳性组高级别CIN检出率为14.46%，在HR-HPV阴性组高级别CIN检出率为1.30%，两组间差异有统计学意义（x2=1，P<0.05）。HPV在ASCUS患者中检测高级别CIN和浸润癌的敏感度和特异度为：92.31%和86.39%，阳性预测值和阴性预测值为：14.46%和99.21%。结论 HR-HPV阳性的ASCUS患者高级别CIN发生率高，应行阴道镜检查，HR-HPV阴性的ASCUS患者发生高级别CIN的风险低，可随诊。
关键词：不典型鳞状细胞；高危型人乳头瘤病毒；宫颈细胞学；高级别宫颈上皮内瘤变
High Risk HPV Testing for the Significance of the Atypical Squamous Cells of the Cervix is Not Clear
YANG Ai-hua，ZHU Xiao-ling，GUO Min
（Department of Gynaecology，Tianjin Haibin People"s Hospital，Tianjin 300280，China）
Abstract：Objective To investigate the clinical significance of atypical squamous cell of undetermined significancein（ASCUS）cervical smear，its management strategies and the value of high rist human papillomavirus（HR-HPV）test.Methods 160 patients with ASCUS tested by thin-prep-1iquid-based cytology were undergone with HR-HPV testing，colposcopy and cervical biopsies.Results The frequency of high level CIN in HR-HPV positive group and negative group was 14.46%and 1.30%.The difference was statistically significant（x2=1，P<0.05）.The sensitivity and specificity of HR-HPV-positive in diagnosing high level CIN and invasive carcinoma were 92.31%and 86.39%，the positive predictive value and negative predictive value was 14.46%and 99.21%.Conclusion HR-HPV positive patients with ASCUS high incidence...
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