叶酸受体介导的宫颈特殊染色法与TCT联合HPV在宫颈病变初筛中的对比研究
[摘要] 目的 探討叶酸受体介导的宫颈特殊染色法(FRD)与薄层液基细胞学检测技术(TCT)联合人乳头瘤病毒(HPV-DNA高危型)在宫颈病变初筛中的应用价值。 方法 选取2016年1月~2017年1月期间来我院妇科门诊就诊的156例患者作为研究对象,宫颈外口及宫颈管两部分行FRD上皮组织特殊染色,并同时行TCT和HPV-DNA(高危型)检测,如其中有一项异常行阴道镜检查,根据阴道镜评估结果,在宫颈取组织活检行病理检查,以组织病理CIN2+为阳性标准,统计分析FRD染色,TCT联合HPV-DNA(高危型)检测与组织病理学检查对比,敏感性,特异性,阳性预测值,阴性预测值,比较两种方法的诊断结果。 结果 FRD染色的敏感性为80.1%,特异性为72.6%,阳性预测值为76.5%,阴性预测值为77.4%,TCT结果的敏感性为82.8%,特异性为48.4%,阳性预测值为63.5%,阴性预测值为70.1%;HPV-DNA结果的敏感性为92.8%,特异性为35.4%,阳性预测值为92.5%,阴性预测值为94.1%。 结论 FRD作为较为准确,简便,快速,经济的检查手段,对前宫颈癌前病变有临床意义,是宫颈病变的重要临床评估标准。
[关键词] FRD;TCT;HPV;宫颈病变;应用价值
[中图分类号] R737.33 [文献标识码] A [文章编号] 2095-0616(2017)11-239-03
Contrastive study of folate receptor mediated cervical special staining and TCT combined with HPV in the screening of cervical lesions
ZHANG Ping TAO Ruihuan CAO Huitao
Nanhai District Fifth People"s Hospital,Foshan 528000,China
[Abstract] Objective To explore the application value of folate receptor mediated cervical special staining (FRD) Thin layer liquid based cytology test (TCT) combined with Human papillomavirus (HPV-DNA high risk type) in the screening of cervical lesions. Methods 156 cases of cured in gynecological outpatients of our hospital from January 2016 to January 2017 were selected as the study object.Special staining of FRD epithelial tissue was used in the two parts of the cervix and cervical canal.At the same time,TCT and HPV-DNA (high-risk) detection were also used.If one of th...
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