滋肾凉血调周法对子宫内膜异位症合并不孕患者血清及内膜VEGF表达的影响
[摘要] 目的 通过观察中药滋肾凉血调周法对子宫内膜异位症合并不孕患者的血清及在位内膜VEGF水平的影响，探讨中药滋肾凉血调周法提高子宫内膜容受性的作用机制。 方法 选取120例内异症合并不孕患者，随机单盲分为中药组60例和西药组60例。中药组：轻度患者术后第一次月经来潮开始中药口服；中重度患者术后月经第一天皮下注射GnRH-a，隔28 d一次，共三针，第三针后30 d开始服用中药。西药组：轻度患者术后观察6个月经周期；中重度患者术后月经第一天皮下注射GnRH-a，隔28 d一次，共三针。采用ELISA方法检测中药滋肾凉血调周法治疗60例内异症合并不孕患者的前后血清VEGF水平及在位内膜VEGF阳性表达。 结果 治疗后中药组的血清VEGF水平及在位内膜VEGF阳性表达低于西药组，差异有统计学意义（P<0.05）。 结论 中药滋肾凉血调周法可以明显降低EMT患者的血清VEGF水平及在位内膜VEGF阳性表达，提高子宫内膜容受性。
[关键词] 滋肾凉血；子宫内膜异位症；不孕；VEGF
[中图分类号] R711.71 [文献标识码] B [文章编号] 1673-9701（2016）24-0156-04
blood and regulating menstrual cycle method in improvement of endometrial receptivity by observing the influence of nourishing kidney cooling blood and regulating menstrual cycle method on serum and endometrial VEGF expression in patients with endometriosis combined with infertility. Methods 120 patients with endometriosis combined with infertility were selected and randomly and single-blindly divided into the TCM group and the western medicine group， each with 60 cases. Patients with mild symptoms in the TCM group were orally given TCM since first menstruation after operation， and those with middle to severe symptoms were subcutaneously injected with GnRH-a at the first day of menstruation， once for 28 days， three times in total， and were orally given TMC at 30 days after the third injection. Patients with mild symptoms in the western medicine group were observed for 6 cycles of menstruation， and those with middle to seve...
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