慢性心力衰竭患者血浆同型半胱氨酸的水平及意义
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【摘要】 目的:探讨慢性心力衰竭(CHF)患者血浆同型半胱氨酸(Hcy)的水平及意义。方法:选取200例患者,其中心功能正常患者100例(对照组),CHF患者100例(CHF组)。按照美国纽约心脏病学会(NYHA)心功能分级标准将CHF患者分为Ⅱ、Ⅲ、Ⅳ级组。比较分析非CHF患者及CHF患者Hcy、N端B型脑钠肽前体(NT-proBNP)水平及左室射血分数(LVEF)。结果:CHF组的Hcy水平高于对照组(P<0.05),且不同心功能分级(Ⅱ~Ⅳ级)患者之间的Hcy水平比较差异有统计学意义(P<0.05);CHF组的NT-proBNP水平高于对照组(P<0.05),且不同心功能分级(Ⅱ~Ⅳ级)患者之间的NT-proBNP水平比较差异有统计学意义(P<0.05);CHF组的LVEF低于对照组(P<0.05),且不同心功能分级(Ⅱ~Ⅳ级)患者之间的LVEF比较差异有统计学意义(P<0.05)。CHF组血浆Hcy水平与NT-proBNP水平呈正相关(r=0.564,P<0.05),与LVEF呈负相关(r=0.455,P<0.05)。结论:CHF患者血浆Hcy升高,Hcy水平有可能作为CHF的重要标志物之一。
【关键词】 慢性心力衰竭; 同型半胱氨酸; N端B型脑钠肽前体; 左室射血分数
【Abstract】 Objective:To observe the concentration and clinical meaning of plasma homocysteine on chronic heart failure patients(CHF).Method:There were 200 patients, 100 of them do not have CHF (control group),100 of them have CHF(CHF group).The CHF patients were separated as group Ⅱ,group Ⅲ,group Ⅳ according to the America New York Heart Association (NYHA).The plasma homocysteine,N-terminal B-type natriuretic peptide (NT-proBNP) and left ventrical eject function(LVEF) were compared on all of the patients.Result:The plasma homocysteine was higher on the group CHF than on the control group(P<0.05).The plasma homocysteine was different from group Ⅱ to group Ⅲ and group Ⅳ(P<0.05).The NT-proBNP was higher on the group CHF than on the control gro...
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