持续小剂量微泵滴注奥美拉唑治疗新生儿应激性溃疡的临床疗效及安全性分析
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摘要：目的 探讨持续小剂量微泵滴注奥美拉唑治疗新生儿应激性溃疡的效果及安全性。方法 有新生儿应激性溃疡92例分为两组，分别给予奥美拉唑静脉滴注治疗（对照组46例）及奥美拉唑持续小剂量微泵滴注治疗（观察组46例），评估患儿治疗效果。结果 观察组患儿治疗有效率（100%）与对照组患儿（97.8%）相比无显著性差异（P>0.05）。观察组患儿出血停止时间、黑便停止时间均低于对照组，差异显著（P<0.05）。患儿治疗期间均未出现明显不良反应。结论 持续小剂量微泵滴注奥美拉唑治疗新生儿应激性溃疡临床效果及安全性都极好，患儿症状改善更为迅速。
关键词：奥美拉唑；新生儿应激性溃疡；微泵滴注
Abstract：Objective To investigate the effect of continuous low dose of micro pump infusion of omeprazole in the treatment of neonatal stress ulcer effect and safety. Methods Neonatal stress ulcer in 92 cases were divided into two groups， were given omeprazole intravenous infusion therapy （46 cases in the control group） and low dose omeprazole sustained micro pump infusion therapy （the observation group 46 cases）， evaluated the therapeutic effect. Results The observation group with the treatment efficiency （100%） and the control group （97.8%） compared with no significant difference （P > 0.05）. The observation group with bleeding time， melena stop time were lower than the control group， the difference was significant （P < 0.05）. There were no obvious adverse reactions in patients during the treatment. Conclusion Low dose continuous micro pump infusion of omeprazole in the treatment of neonatal stress ulcer clinical efficacy and safety are excellent， the symptoms improved more rapidly.
Key words：Omeprazole； Neonatal stress ulcer； Micro pump infus...
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