持续小剂量微泵滴注奥美拉唑治疗新生儿应激性溃疡的临床效果及安全性评价
【摘要】 目的:探讨持续小剂量微泵滴注奥美拉唑治疗新生儿应激性溃疡的效果及安全性。方法:将2016年3月-2017年8月因新生儿应激性溃疡于笔者所在医院治疗的80例患者纳入研究,并依据随机数字表法分组。对照组40例采用注射用奥美拉唑[0.8 mg/(kg>d)]治疗,分2次滴注,观察组40例则采用注射用奥美拉唑[0.8 mg/(kg>d)]微泵治疗,均以3 d为一疗程。比较两组胃内pH值改善情况及临床疗效情况。结果:治疗后6、12、24、72 h时观察组胃内pH值均高于对照组(P<0.05);观察组总有效率为97.50%(39/40),高于对照组的80.00%(32/40),差异有统计学意义(P<0.05);治疗过程中对照组有1例患者出现皮疹,观察组未发生不良反应,差异无统计学意义(P>0.05)。结论:持续小剂量微泵滴注奥美拉唑治疗新生儿应激性溃疡效果显著,可改善临床症状,促进疾病康复,值得推广。
【关键词】 持续小剂量微泵滴注; 奥美拉唑; 新生儿应激性溃疡; 安全性
doi:10.14033/j.cnki.cfmr.2018.17.012 文献标识码 B 文章编号 1674-6805(2018)17-00-03
Clinical Efficacy and Safety Evaluation of Continuous Low-dose Micropump Infusion of Omeprazole in the Treatment of Stress Ulcer in Neonates/MO Shaomin.//Chinese and Foreign Medical Research,2018,16(17):-30
【Abstract】 Objective:To investigate the effect and safety of continuous low dose micropump infusion of Omeprazole in the treatment of neonatal stress ulcer.Method:From March 2016 to August 2017,80 cases of neonatal stress ulcer in our hospital were randomly divided into two groups.The control group included 40 patients were treatment by Omeprazole[0.8 mg/(kg>d)],2 times/day.The observation group also included 40 patients were injected Omeprazole
[0.8 mg/(kg>d)] by micro pump therapy,two groups treatment for 3 days.Gastric pH improvement and clinical curative effect of the two groups were compared.Result:The pH values in the stomach of the observation group were higher than those in the control group at 6 h,12 h,24 h...
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