兔颈总动脉破裂粥样硬化斑块模型炎症因子的表达
[摘要] 目的 探索兔颈总动脉破裂粥样硬化斑块模型血清炎症因子的水平。 方法 将30只健康雄性新西兰白兔随机分为3组,对照组(n=10)、高脂饮食组(n=10)和球囊损伤组(n=10)。饲养8周后,采用'腔外负压“法诱导斑块破裂,观察兔血清脂蛋白、白介素-6及hs-CRP水平的变化,彩色多普勒超声鉴定斑块形成。 结果 高脂饲养8周后,球囊损伤组、高脂饮食组的血清脂蛋白水平、颈总动脉血流速度、IMT显著高于对照组(P<0.05),而颈总动脉内径低于对照组;血清IL-6、hs-CRP水平显著高于对照组,高脂饮食组与球囊损伤组间差异有统计学意义。 结论 炎症反应参与动脉粥样硬化的形成,在粥样硬化斑块破裂中扮演重要角色;为破裂斑块的形成提供了一定的动物模型理论基础。
[关键词] 兔;动物模型;颈动脉粥样硬化斑块;炎症因子
[中图分类号] R743[文献标识码] A[文章编号] 1674-4721(2014)05(b)-0004-04
The express of inflammatory factor in animal model of carotid atherosclerosis plaque rupture
LIU Xin-ye YANG Dong-wei▲ CHENG Yong LIU Min CHI Hao
Department of Cardiology,Zhengzhou Central Hospital Affiliated to Zhengzhou University,Zhengzhou 450007,China
[Abstract] Objective To explore the express of inflammatory factor in animal model of carotid atherosclerosis plaque rupture. Methods 30 healthy New Zealand white male rabbits were randomly divided into 3 groups including control group (n=10),carotid lesion group with balloon dilation (n=10) and the high fat-diet group (n=10).The concentrations of serum lipoprotein,interleukin-6,hypersensitive C reactive protein,internal diameter of carotids,intima-media thickness and blood flow rate of carotids were obtained used by color Doppler ultrasound respectively,plaque ruptures were triggered by negative pressures of intra-cavity in carotids injury group,the relationship among inflammatory factor,the severity of atherosclerosis and the achievement ratio of carotid atherosclerosis plaque rupture were evaluat...
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