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紫杉醇脂质体对非小细胞肺癌患者的抗肿瘤作用研究

材料写作网    时间: 2021-03-26 04:06:23     阅读:

【摘要】 目的:探究紫杉醇脂质体对非小细胞肺癌(non-small cell lung cancer,NSCLC)患者的抗肿瘤作用。方法:选取九江市第三人民医院2013年8月-2015年8月收治的160例非小细胞肺癌患者作为研究对象,依据用药情况随机分为对照组和观察组,各80例,观察组采用紫衫醇脂质体(135 mg/m2,静脉滴注3 h,第1天),对照组应用传统紫杉醇(135 mg/m2,静脉滴注3 h,第1天),观察组与对照组都以顺铂治疗为基础。21 d为1个周期,化疗2、4、6个周期后,比较两组患者用药后治疗情况。结果:化疗6个周期后,观察组有效率高于对照组,差异有统计学意义(P<0.05)。化疗2个周期后,观察组的恶心呕吐、疲乏无力、脱发发生率均低于对照组,差异均有统计学意义(P<0.05)。结论:紫杉醇脂质体联合顺铂治疗非小细胞肺癌有良好的效果,此外,还会减少不良反应,值得在临床上大力推广。

【关键词】 紫杉醇脂质体; 非小细胞肺癌; 抗肿瘤

Study of Anti-tumor Effect of Paclitaxel Liposome in Patients with Non-small Cell Lung Cancer/ZHOU Lin-ping,LI Xuan.//Medical Innovation of China,2016,13(33):123-126

【Abstract】 Objective:To explore the anti-tumor effect of paclitaxel liposome in patients with non-small cell lung cancer.Method:160 patients in the Third People’s Hospital of Jiujiang City from August 2013 to August 2015 were selected as study objects,according to the use of the medication,patients were divided into the control group and observation group,80 cases in each group.The observation group received dose of Paclitaxel Liposome 135 mg/m2 by 3 h intravenous injection on the first day,the control group received dose of conventional Paclitaxel 135 mg/m2 by 3 h intravenous injection on the first day,the observation group and the control group were treated with cisplatin as the foundation.21 d for 1 cycle,after chemotherapy for 2,4,6 cycles,the situation of the two groups were compared after treatment.Result:After 6 cycles of chemotherapy,the effective...

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