质子泵抑制剂与硫糖铝对危重患者呼吸机相关性肺炎影响的研究
[摘要] 目的 探讨降低呼吸机相关性肺炎（VAP）发生率的方法。 方法 选取符合入选标准的接受气管插管机械通气的患者为研究对象，将患者随机分为研究组和对照组，两组患者的常规治疗方法相同，研究组应用硫糖铝混悬液2 g，3次/d鼻饲；对照组应用泮托拉唑40 mg，2次/d静脉滴注。记录急性上消化道出血（AUGIB）和VAP的发生情况。 结果 两组患者轻中度AUGIB（黑便和咖啡色胃液）的发生率比较，差异无统计学意义（P>0.05）；对照组VAP的发生率明显高于研究组（P<0.05）。 结论 对于有轻中度应激性溃疡风险的患者，应用硫糖铝在较好预防AUBIG发生的同时可明显降低发生VAP的风险。
[关键词] 应激性溃疡；呼吸机相关性肺炎；危重患者；质子泵抑制剂；硫糖铝
[中图分类号] R563.1+9 [文献标识码] A [文章编号] 1674-4721（2014）04（a）-0082-03
[Abstract] Objective To explore the method of decreasing the incidence rate of ventilator-associated pneumonia （VAP）. Methods Patients met inclusion criteria who received tracheal intubation and mechanical ventilation were selected as subjects and they were randomly divided into the experimental group and the control group.All patients were given the same conventional treatment，while the experimental group was given sucralfate of suspension 2 g，3 times one day by nasal feeding and the control group was given pantoprazole 40 mg by intravenous administration，2 times one day.The incidence of acute upper gastrointestinal bleeding and VAP of the two groups was recorded. Results There was a statistical difference of the incidence rate of mild and moderate acute upper gastrointestinal bleeding of the two groups；the incidence rate of VAP of the control group was significantly higher than that of the experimental group （P<0.05）. Conclusion For the patients with mild and moderate risk of stress ulcer，sucralfate is applied to prevent better AUBIG and decrease the incidence rate of VAP at the same...
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