Effect,of,Cx32,over-expression,on,cell,proliferation,,migration,,and,invasion,of,hepatocellular,carcinoma,cell,line,Huh7,and,its,mechanism
JI Wen-bin, LV Zhen-yu, CHENG Qian-qian, ZHOU Xue-li, WANG Wei, YANG Yan
Department of Medical Oncology, The First Affiliated Hospital of Bengbu Medical College, Bengbu 233004, China
Keywords:
ABSTRACT
Liver cancer is one of the most common malignant tumors in China, of which hepatocellular carcinoma (HCC) accounts for about 75%～85%.Those patients have insidious early symptoms,and are usually diagnosed in the middle and advanced stages of the disease with a high mortality rate[1,2].Finding new targets for HCC and developing new drugs against these targets will provide help to improve the prognosis of HCC.Gap junction protein 32(Cx32) is also known as β1 connexin.As a major member of the gap junction (GJ) family, Cx32 is highly expressed in normal hepatocytes and forms GJ channels in the human liver, with GJs composed of Cx32 accounting for approximately 90% of total GJ function in the liver[3].Controversy remains regarding the role of Cx32 in the development of HCC.For example, Fujimoto et al.[4]suggested that Cx32 is a tumor suppressor gene, and its abnormal number and distribution may be associated with the development of HCC in humans.Previous studies by our team have also found that the carcinogenesis process of hepatocytes is closely related to the reduction or loss of Cx32, and restoring Cx32 expression may be a promising strategy for HCC treatment[5].However, there are some studies that suggest that Cx may play an important role in promoting tumor cell invasion and tumor metastasis.For example,accumulation of Cx32 protein in the cytoplasm of Huh7 promotes invasion and metastasis of HCC cells[6], and expands the cancer stem cell population in Huh7 cells by enh...
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